We are interested in the underlying physics of transport phenomena across membranes (a.k.a. translocation). For example, we quantify the permeation of antibiotic molecules across bacterial channels, we investigate the condutance phenomena at molecular level and the gating mechanisms in nanopores.
Knowledge on selective permeation can be used in the area of
nanobiotechnology: using natural or engineered channels as molecular sieves to control substrate permeation. For example we develop such nanometer sized capsules containing enzymes as inside cell reporter.
Multidrug efflux (MDE) transporters are major contributors to bacterial resistance towards antibiotics and naturally occurring toxic substances. The overall goal of our research is to identify and characterize MDE pumps in environmental bacteria and to gain in-depth knowledge about their regulation, structure, mechanism of transport and natural function.
Our research is performed in collaboration with:
The projects have received funding from the European Union’s Seventh Framework Programme for research, technological development and demonstration under grant agreement no 607694, 604434, 604237, 604182 and IMI115525, and from the EFPIA companies.
Prof. Dr. Mathias Winterhalter, Professor of Biophysics (Focus Area: Health – Life Sciences & Chemistry – Jacobs University Bremen gGmbH) Email: firstname.lastname@example.org – Tel: +49 421 200-3248 / Fax: +49 421 200-3249
Ms. Alexandra Irina Lazar, IMI Project Manager – Email: email@example.com